Medical Office Space in South San Francisco.
South San Francisco medical offices cluster along El Camino Real near Kaiser's hospital, on Westborough Boulevard and on Oyster Point Boulevard.
South San Francisco Healthcare Real Estate Market
South San Francisco has 65,239 residents (California Department of Finance, 2026) and one acute-care hospital, Kaiser Permanente's South San Francisco Medical Center at 1200 El Camino Real. HCAI lists it with 120 licensed beds and a basic emergency department, which Kaiser says is open 24 hours. Kaiser also runs its Cancer Treatment Center at 220 Oyster Point Boulevard; a sign on East Grand Avenue calls South San Francisco the "Birthplace of Biotechnology," a nod to Genentech, which opened there in 1976. Outside the Kaiser system, the nearest hospitals are AHMC Seton Medical Center at 1900 Sullivan Avenue in Daly City and Sutter Health's Mills-Peninsula Medical Center at 1501 Trousdale Drive in Burlingame. Independent medical and dental offices are spread along El Camino Real near the Kaiser campus and on Westborough Boulevard, where 2400 Westborough houses several dental practices and 91 Westborough has sleep-diagnostic and dialysis-access centers. San Mateo County runs a South San Francisco clinic at 306 Spruce Avenue. Because the city's only hospital is a Kaiser facility, practices outside the Kaiser network should plan hospital affiliation around Seton or Mills-Peninsula.
Profile updated
Where Medical Offices Cluster in South San Francisco
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El Camino Real (Kaiser campus)
Kaiser Permanente South San Francisco Medical Center (1200 El Camino Real), the city's only hospital, with independent medical and dental offices along the El Camino Real corridor.
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Westborough Boulevard
Dental practices at 2400 Westborough Blvd; sleep-diagnostic and dialysis-access centers at 91 Westborough Blvd.
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Oyster Point Boulevard
Kaiser Permanente Cancer Treatment Center at 220 Oyster Point Blvd.
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Spruce Avenue
San Mateo County clinic at 306 Spruce Ave.
Major Health Systems
- • Kaiser Permanente South San Francisco Medical Center
- • San Mateo Medical Center (County of San Mateo clinic)
- • AHMC Seton Medical Center (Daly City)
- • Mills-Peninsula Medical Center (Sutter Health, Burlingame)
Neighboring Markets
Current Listings in South San Francisco
As of October 8, 2026
No active listings in South San Francisco at this time.
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Frequently Asked Questions
View All FAQs? What hospital serves South San Francisco?
The city's only acute-care hospital is Kaiser Permanente's South San Francisco Medical Center at 1200 El Camino Real. HCAI lists it with 120 licensed beds and a basic emergency department, and Kaiser says the emergency department is open 24 hours. Kaiser also runs a Cancer Treatment Center at 220 Oyster Point Boulevard. For non-Kaiser hospital care, the nearest options are AHMC Seton Medical Center in Daly City and Sutter Health's Mills-Peninsula Medical Center in Burlingame.
? Where are medical and dental offices in South San Francisco?
Independent practices are spread along El Camino Real, including near the Kaiser campus at 1200 El Camino Real, and on Westborough Boulevard. The building at 2400 Westborough Boulevard houses several dental practices, and 91 Westborough Boulevard has sleep-diagnostic and dialysis-access centers. San Mateo County operates a clinic at 306 Spruce Avenue, and Kaiser's Cancer Treatment Center is at 220 Oyster Point Boulevard.
? Does the biotech industry affect medical office options in South San Francisco?
South San Francisco calls itself the "Birthplace of Biotechnology" after Genentech opened there in 1976, and companies such as Amgen and Exelixis also have operations in the city. Kaiser has placed its Cancer Treatment Center at 220 Oyster Point Boulevard. The independent medical and dental offices that serve local patients, however, are concentrated along El Camino Real, where Kaiser's hospital sits at 1200 El Camino Real, and on Westborough Boulevard, at buildings such as 2400 and 91 Westborough.
? What factors should medical practices consider when choosing a location?
Key site selection factors include: proximity to referral sources and hospitals; patient demographics and population density; visibility and accessibility (parking ratios, ADA compliance); competitor proximity; zoning and permitted uses; co-tenancy with complementary healthcare providers; and ease of access for patients including public transit options in urban markets.
? What is a "medical corridor" or "healthcare district"?
Medical corridors or healthcare districts are geographic areas with high concentrations of healthcare facilities, often anchored by hospitals. Locating within these areas can provide benefits including patient convenience, referral network proximity, shared parking arrangements, and established wayfinding. The Bay Area has several prominent medical corridors in cities like Palo Alto, San Jose, and San Francisco.
? What is a second-generation medical space?
Second-generation (2nd gen) medical space is a suite previously occupied by a medical tenant that retains clinical infrastructure like plumbing, electrical, and possibly exam room layouts. Leasing 2nd gen space can significantly reduce build-out costs and timelines compared to shell condition, though modifications may still be needed to suit your specific practice requirements.
Sources
- California Department of Finance, E-1 City Population Estimates (Jan. 1, 2026)
- HCAI: Kaiser Foundation Hospital - South San Francisco facility profile
- Kaiser Permanente: South San Francisco Medical Center
- HCAI: Mills-Peninsula Medical Center facility profile
- Wikipedia: South San Francisco ("Birthplace of Biotechnology")
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