Medical Office Space in National City.
National City medical offices center on Paradise Valley Hospital, with buildings on Euclid Avenue and community clinics on E. 14th St and Highland Ave.
National City Healthcare Real Estate Market
National City has 58,701 residents (California Department of Finance, 2026) and its own acute-care hospital, Paradise Valley Hospital at 2400 East Fourth Street. The hospital traces its roots to a sanitarium founded in the 1880s, was run for decades by Seventh-day Adventists, and has been owned by Prime Healthcare since 2006, when Adventist Health sold it. It provides 24-hour emergency care, interventional radiology, acute rehabilitation and behavioral health services. Medical offices concentrate near the hospital on Euclid Avenue, where buildings at 502, 610 and 655 Euclid Avenue are marketed as the Paradise Valley Prime Healthcare medical office campus; 655 Euclid is a 62,540-square-foot building. Community health centers are a large part of the city's outpatient care. San Ysidro Health, a federally qualified health center, runs a clinic at 601 E. 14th Street with adult and family medicine, pediatrics, women's health, dental, lab and X-ray, and behavioral health services, and La Maestra Community Health Centers has a site at 217 Highland Avenue. The nearest other hospitals are in Chula Vista: Scripps Mercy Hospital Chula Vista on H Street and Sharp Chula Vista Medical Center on Medical Center Court. Practices that want to be next to the hospital should start with the Euclid Avenue buildings.
Profile updated
Where Medical Offices Cluster in National City
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Euclid Avenue & E. Fourth Street
Paradise Valley Hospital (2400 E. Fourth St) and the Paradise Valley Prime Healthcare medical office buildings at 502, 610 and 655 Euclid Ave.
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E. 14th Street & Highland Avenue
Community clinics, including San Ysidro Health National City (601 E. 14th St, Suite 201) and La Maestra Community Health Centers (217 Highland Ave).
Major Health Systems
- • Paradise Valley Hospital (Prime Healthcare)
- • San Ysidro Health
- • La Maestra Community Health Centers
Neighboring Markets
Current Listings in National City
As of October 8, 2026
No active listings in National City at this time.
Browse all propertiesNational City Case Studies
No case studies for National City currently available.
Browse all projectsFrequently Asked Questions
View All FAQs? Does National City have a hospital?
Yes. Paradise Valley Hospital at 2400 East Fourth Street is a general acute-care hospital owned by Prime Healthcare, which bought it from Adventist Health in 2006. It provides 24-hour emergency care, interventional radiology, acute rehabilitation and behavioral health services. The nearest other hospitals are in Chula Vista: Scripps Mercy Hospital Chula Vista at 435 H Street and Sharp Chula Vista Medical Center at 751 Medical Center Court.
? Where are the medical office buildings near Paradise Valley Hospital?
The main group is on Euclid Avenue near the hospital, where buildings at 502, 610 and 655 Euclid Avenue are marketed together as the Paradise Valley Prime Healthcare medical office campus. The 655 Euclid building has 62,540 square feet, and the 610 Euclid building is a three-story, 14,744-square-foot medical office building; both were built in 1970. Paradise Valley Hospital is the only acute-care hospital in National City, so these buildings are the closest medical office space to its emergency department and inpatient services.
? What community health centers operate in National City?
San Ysidro Health, a federally qualified health center, runs a clinic at 601 E. 14th Street, Suite 201, offering adult and family medicine, pediatrics, women's health, behavioral health, lab and X-ray, and children's and adult dentistry, with sliding-scale fees for uninsured patients. La Maestra Community Health Centers operates a National City site at 217 Highland Avenue. San Ysidro Health also provides professional interpreter services in multiple languages on request.
? What factors should medical practices consider when choosing a location?
Key site selection factors include: proximity to referral sources and hospitals; patient demographics and population density; visibility and accessibility (parking ratios, ADA compliance); competitor proximity; zoning and permitted uses; co-tenancy with complementary healthcare providers; and ease of access for patients including public transit options in urban markets.
? What is a second-generation medical space?
Second-generation (2nd gen) medical space is a suite previously occupied by a medical tenant that retains clinical infrastructure like plumbing, electrical, and possibly exam room layouts. Leasing 2nd gen space can significantly reduce build-out costs and timelines compared to shell condition, though modifications may still be needed to suit your specific practice requirements.
? What parking ratio do medical offices need?
Medical offices typically require higher parking ratios than general office space due to patient turnover throughout the day. A common standard is 5-6 spaces per 1,000 square feet, compared to 3-4 for general office. High-volume practices like urgent care or imaging centers may need even more. Verify the property's parking allocation before signing a lease.
Sources
- California Department of Finance, E-1 City Population Estimates (Jan. 1, 2026)
- HCAI: Paradise Valley Hospital
- FOX 5 San Diego: Paradise Valley Hospital services and Prime Healthcare (Dec. 2025)
- Wikipedia: Paradise Valley Hospital (history and 2006 Prime acquisition)
- Cushman & Wakefield: 655 Euclid Ave medical office building
- San Ysidro Health: National City clinic
- La Maestra Community Health Centers: locations
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